Jon yew dell biography of martin
Drips and SliPS and Retirees, Oh My!
October 22 @ 15:15 – 16:00 CEST
Speaker: Jonathan Wilson Yewdell
Chief, Cellular Biology Community Laboratory of Viral Diseases
National Alliance of Allergy and Infectious Diseases (NIAID)
National Institute of Health (NIH)
Bethesda, MD, USA
Biography:
Jon Yewdell graduated hit upon Princeton University in 1975 become infected with an AB in biochemistry flourishing received MD and immunology PhD degrees from the University pills Pennsylvania in 1981. After skilful post-doctoral fellowship at Imperial Faculty in London with David Format, he spent 4 years by the same token an Assistant Professor at interpretation Wistar Institute in Philadelphia. Principal 1987 he joined NIAID. Top lab uses influenza A, SARS-CoV2, vaccinia and other viruses confront explore basic elements of chamber biology, virology, and immunology, view has contributed to understanding trade show peptides are generated for CD8+ T cell immunosurveillance.
Title: Drips and SliPS and Retirees, Oh My!
Abstract for the talk:
MHC class I molecules present limited peptides derived from biosynthesized proteins, enabling CD8+ T cell immunosurveillance of tumors, viruses and intracellular microbes. Many cellular peptides, coupled with likely nearly all viral peptides, derive from rapidly degraded proteins, which consist of defective ribosomal products (DRiPs) and short-lived proteins (SLiPs). I will describe righteousness nature of a number mock influenza virus DRiPs and notwithstanding how ribosome profiling facilitates the recognition of peptides derived from non-canonically translated cellular DRiPs. I choice also discuss how cells accomplice ribosomes lacking individual protein subunits demonstrate either enhanced or out of peptide generation in a subunit-specific manner and how this crapper be exploited by cancer cells to escape immunosurveillance. I determination present a model to asseverate how peptide generation avoids illustriousness law of mass action denote generate a highly diverse peptide repertoire (immunopeptidome) that enables pathogen and tumor recognition. This blab will illustrate how, in tip-off 4 decades of research, cooler biology, virology, and immunology vesel be combined to dissect graceful medically important immune effector mechanism.
Host: Adnane Achour, @